Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target K_i: 310 nM for human recombinant type II arginase, pH 7.5

Product does not compete with ATP.

Primary Targetarginase 1, arginase 2

General description

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.Kim, N.N., et al. 2001. Biochemistry40, 2678.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

Warning

Toxicity: Harmful (C)